ARREST-AF

Implications of aggressive cardiac risk factor management on the catheter ablation for AF

ANZCTR Trial ID: ACTRN12613000444785

Catheter ablation of atrial fibrillation (AF) has evolved as an effective therapy for drug-refractory AF, and the indications have broadened in recent years. Despite decreased procedural times, reduced complication rates, post-ablation freedom from AF has not improved proportionately in recent years. Metabolic syndrome (MS) and its components, including obesity, hypertension, diabetes, and dyslipidemia in conjunction with obstructive sleep apnoea, excessive alcohol intake and smoking has been associated with increased incidence of AF.

However, the impact of modifications of these risk factors on recurrence of AF after catheter ablation is unclear and has not been tested prospectively. Also, these patients are typically not included in risk-factor reduction programs. The purpose of the study is to evaluate the impact of a structured weight managment program as part of the management of AF. It is also intended to assess the effect of weight reduction on the efficacy of AF following catheter ablation and the effect of weight and risk factor management on autonomic tone/pro-arrhythmic substrate.

Please contact Jonathon Foote for more information.

  • Professor Sanders says...

     
    Atrial fibrillation is a consequence of several reversible risk factors - high blood pressure, diabetes, obesity, sleep apnoea, and excessive alcohol. Your management of atrial fibrillation must include strict control of these risk factors.